The article is devoted to the specific use of theoretical and methodological provisions of the international business of domestic oil and gas companies in practical entrepreneurship. It addresses the following issues— the importance of the agreement of OPEC+; international oil and gas business as a system, criteria of allocation of categories of oil and gas majors; options indicators and international megaprojects; the changing of the vector of cooperation of high-profile domestic companies with foreign partners. The implementation of the agreement will change the balance of supply and demand in the world oil market. As a result, prices will rise to 58 to 63 dollars per barrel. This price is acceptable for the domestic core businesses, and for Russia, which is one of the main manufacturers and main suppliers of this resource. However, probably the level of prices can persist for a relatively short period because this indicator affects a large number of factors. It has been established that the participation of foreign companies in business projects is beneficial for Russian companies, since they are investors and innovators, which help to accelerate the development of deposits or the construction of infrastructure facilities. It is determined that the most important parameter, which can characterise the position of a major, is a high level of competitive advantages, which is measured by indicators linked to a specific year. The conclusion is that the Russian specialised companies successfully adapt to new macroeconomic conditions, including prices for hydrocarbons and increase their competitive advantage, increase production efficiency, increasing the volumes of supply to world markets.